| Symposium |
| Some effects of lead contamination on liver and gallbladder bile |
| Péter Sipos1*, Klára Szentmihályi2, Erzsébet Fehér3, Mohamed Abaza4, Mihály Szilágyi5, Anna Blázovics6,2 |
| 12nd Department of Surgery, Semmelweis University, Budapest, Hungary, 2Chemical Institute, Chemical Research Centre, Hungarian Academy of Sciences, Budapest, Hungary, 3Department of Anatomy, Semmelweis University, Budapest, Hungary, 4Department of Poultry Production, Faculty of Agriculture, Alexandria, Egypt, 5Research Institute of Animal Breeding and Nutrition, Herceghalom, Hungary, 62nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary |
| Lead can cause liver damage in which free radical reactions are involved. In order to study the effect of lead on liver and gallbladder, we examined human gallbladder bile after cholecystectomy, as well as the liver and bile of broiler chickens fed with basal diet and contaminated with 400 and 600 mg/kg lead (Pb(CH3COO)2. Concentrations of lead in human bile were determined with inductively coupled plasma optical emissison spectrometer (ICP-OES). Diene-conjugate content as well as thiobarbituric acid reactive compounds in bile were determined by spectrophotometry. In the case of lead poisoning good correlation was observed between the lipid peroxidation parameters of bile and the picture of necrotised tissue observed in a histological study.High lead contamination caused mainly liver damage while cholecystitis was induced by the low concentration of lead, probably, by changing the normal biliary processes. Acta Biol Szeged 47(1-4):139-142 (2003) PDF |
| Key Words: lead, gallstone, bile, lipid peroxidation |
| *Corresponding author. E-mail: speter@kut.sote.hu |